immunodeficiency 13

info · Immune

A T cell deficiency characterized by decreased CD4 T-lymphocyte counts that has_material_basis_in heterozygous mutation in the UNC119 gene on chromosome 17q11.2.

Signs and symptoms

Decreased total T cell count
Decreased total B cell count
Decreased total CD4+ T cell proportion
Decreased total lymphocyte count
Recurrent pneumonia
Recurrent sinusitis
Inverted CD4:CD8 ratio
Recurrent upper respiratory tract infections
Bronchiolitis obliterans organizing pneumonia
Immunodeficiency

Also known as: ICL; IMD13; idiopathic CD4 lymphopenia