immunodeficiency 89

A primary immunodeficiency disease that is characterized by adult onset of recurrent infections, allergies, microcytic anemia, and Crohn disease and that has_material_basis_in homozygous mutation in the CARD10 gene on chromosome 22q13.

Signs and symptoms

• Hypochromic microcytic anemia
• Crohn's disease
• Asthma
• Antinuclear antibody positivity
• Decreased total eosinophil count
• Increased circulating IgG concentration
• Pleural thickening
• Elevated erythrocyte sedimentation rate
• Recurrent lower respiratory tract infections
• Increased circulating IgE concentration

Also known as: immunodeficiency 89 and autoimmunity