immunoglobulin alpha deficiency

A B cell deficiency that is an autosomal recessive disorder that has_material_basis_in mutation in the IgA (CD79 alpha) antigen receptor.

Signs and symptoms

• Autoimmunity
• Recurrent infection of the gastrointestinal tract
• Malabsorption
• Recurrent infections
• Recurrent respiratory infections
• Decreased circulating IgA concentration
• Intermittent diarrhea
• Decreased secretory IgA concentration
• Chronic intestinal candidiasis
• Recurrent sinopulmonary infections

Medications that may treat it

anthrax immune globulin cytomegalovirus immune globulin hepatitis B immune globulin varicella-zoster immune globulin

Also known as: IgA deficiency; gamma-A-globulin deficiency