leukocyte adhesion deficiency 1

A leukocyte adhesion deficiency that has_material_basis_in mutation of the ITGB2 gene on chromosome 21q22.3.

Signs and symptoms

• Gingivitis
• Hyperfibrinogenemia
• Delayed umbilical cord separation
• Elevated circulating C-reactive protein concentration
• Recurrent infections
• Recurrent mucocutaneous candidiasis
• Recurrent bacterial infections
• Chronic diarrhea
• Increased total leukocyte count
• Poor wound healing

Also known as: LAD1; LFA1 immunodeficiency; leukocyte adhesion deficiency type I; lymphocyte function-associated antigen 1 immunodeficiency