major depressive disorder

Persistent low mood and loss of interest, affecting sleep, appetite, energy and concentration. Treatable with therapy and medication.

A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.

Signs and symptoms

• Depression

Also known as: clinical depression; major depression; recurrent major depression; single major depressive episode; unipolar depression