megaloblastic anemia

A macrocytic anemia that is characterized by inhibition of DNA synthesis during red blood cell production.

Signs and symptoms

• Microscopic hematuria
• Proteinuria
• Decreased CSF 5-methyltetrahydrofolate concentration
• Increased mean corpuscular volume
• Absence seizure with eyelid myoclonia
• Paresthesia
• Decreased circulating vitamin B12 concentration
• Confusion
• Malabsorption of Vitamin B12
• Dementia

Medications that may treat it

ferric ammonium citrate ferric citrate ferrous fumarate ferrous gluconate ferrous sulfate folic acid iron sucrose sulfamethoxazole trimethoprim

Also known as: Grasbeck-Imerslund syndrome; Imerslund-Grasbeck syndrome; MGA1 Norwegian type; RH-MGA1; megaloblastic anaemia