Conditions / Musculoskeletal
MELAS syndrome
info · Musculoskeletal · ICD-10: E88.41
A mitochondrial encephalomyopathy that is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, with symptoms of myalgia, motor weakness, headaches, seizures, and stroke-like episodes with acute hemiparesis and sev
A mitochondrial encephalomyopathy that is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, with symptoms of myalgia, motor weakness, headaches, seizures, and stroke-like episodes with acute hemiparesis and severe headaches, and develops_from mutation in mitochondrial genes including MT-TL1, which encodes tRNA proteins.
Signs and symptoms
- Encephalopathy
- Bilateral tonic-clonic seizure
- Myopathy
- Arrhythmia
- Diabetes mellitus
- Hemianopia
- Growth abnormality
- Cerebral visual impairment
- Developmental cataract
- Hemiparesis
Also known as: MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC ACIDOSIS, AND STROKE-LIKE EPISODES