multiple endocrine neoplasia type 1

info · Syndrome · ICD-10: E31.21

A multiple endocrine neoplasia that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas.

Signs and symptoms

Pituitary prolactin cell adenoma
Diarrhea
Increased circulating prolactin concentration
Peptic ulcer
Zollinger-Ellison syndrome
Subcutaneous lipoma
Hypercalcemia
Glucagonoma
Esophagitis
Pancreatic islet cell adenoma

Also known as: MEN type I; Wermer syndrome; Wermer's syndrome