multiple endocrine neoplasia type 2B

info · Syndrome · ICD-10: E31.23

A multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, multiple mucosal neuromas and intestinal ganglioneuromas, and often a marfanoid habitus and other skeletal abnormalities.

Signs and symptoms

Failure to thrive in infancy
Nodular goiter
Myopathy
Hypotonia
Generalized hypotonia
Hyperlordosis
High palate
Elevated circulating calcitonin concentration
Thick lower lip vermilion
Constipation

Medications that may treat it

albiglutide liraglutide semaglutide

Also known as: MEN type IIB; MEN2B; Multiple endocrine neoplasia, type 3; Wagenmann-Froboese syndrome; mucosal neuroma syndrome