multiple synostoses syndrome 3

A multiple synostoses syndrome that is characterized by multiple joint fusions, usually commencing in the hands, conductive deafness, and characteristic facial features, including a broad, tubular-shaped nose and a thin upper vermilion and that has_material_ba

A multiple synostoses syndrome that is characterized by multiple joint fusions, usually commencing in the hands, conductive deafness, and characteristic facial features, including a broad, tubular-shaped nose and a thin upper vermilion and that has_material_basis_in heterozygous mutation in the FGF9 gene on chromosome 13q12.

Signs and symptoms

• Metatarsal synostosis
• Cleft palate
• Humeroradial synostosis
• Limited interphalangeal movement
• Cubitus valgus
• Metacarpal synostosis
• Cutaneous syndactyly of toes
• Hallux varus
• Broad thumb
• Broad hallux