multiple synostoses syndrome 4

A multiple synostoses syndrome that is characterized by fusion of carpal and tarsal bones, as well as conductive hearing loss and that has_material_basis_in heterozygous mutation in the GDF6 gene on chromosome 8q22.

Signs and symptoms

• Otosclerosis
• Overlapping toe
• Broad foot
• Tarsal synostosis
• Pes planus
• Brachydactyly