Nagashima-type palmoplantar keratosis

A nonepidermolytic palmoplantar keratoderma characterized by mild, well-demarcated, diffuse erythematous hyperkeratosis that is nonprogressive after the second decade of life which extends onto the dorsal surfaces of the palms and feet and the Achilles tendon

A nonepidermolytic palmoplantar keratoderma characterized by mild, well-demarcated, diffuse erythematous hyperkeratosis that is nonprogressive after the second decade of life which extends onto the dorsal surfaces of the palms and feet and the Achilles tendon area, with a high frequency of hyperhidrosis on the palms and soles and without flexion contractures or constricting bands that has_material_basis_in homozygous or compound heterozygous mutation in the SERPINB7 gene on chromosome 18q21.33.

Signs and symptoms

• Palmoplantar hyperkeratosis
• Palmoplantar hyperhidrosis
• Hypergranulosis
• Epidermal acanthosis
• Orthokeratotic hyperkeratosis
• Maceration

Also known as: NPPK; PPKN; palmoplantar keratoderma nagashima type