neonatal nephrocutaneous inflammatory syndrome

An autoinflammatory disease characterized by intrauterine growth retardation and premature birth, fragile infection-prone skin, and nephromegaly with tubular dysfunction that has_material_basis_in mutation in homozygous or compound heterozygous mutation in the

An autoinflammatory disease characterized by intrauterine growth retardation and premature birth, fragile infection-prone skin, and nephromegaly with tubular dysfunction that has_material_basis_in mutation in homozygous or compound heterozygous mutation in the EGFR gene on chromosome 7p11.

Signs and symptoms

• Polyhydramnios
• Increased circulating IgE concentration
• Pustule
• Coarctation of aorta
• Epidermal acanthosis
• Failure to thrive
• Dehydration
• Hypertension
• Papule
• Secretory diarrhea

Also known as: neonatal inflammatory skin and bowel disease 2