nephrogenic syndrome of inappropriate antidiuresis

A renal tubular transport disease characterized by inappropriate antidiuretic hormone secretion resulting in inability to excrete a free water load, inappropriately concentrated urine, and undetectable or low plasma arginine vasopressin levels that has_materia

A renal tubular transport disease characterized by inappropriate antidiuretic hormone secretion resulting in inability to excrete a free water load, inappropriately concentrated urine, and undetectable or low plasma arginine vasopressin levels that has_material_basis_in hemizygous gain-of-function mutation in the AVPR2 gene on chromosome Xq28.

Signs and symptoms

• Elevated systolic blood pressure
• Reduced blood urea nitrogen
• Decreased circulating renin concentration
• Hyponatremia
• Hypernatriuria
• Hyposthenuria
• Decreased serum creatinine
• Generalized-onset seizure
• Irritability
• Abnormal circulating aldosterone concentration

Also known as: NSIAD