Conditions / Genetic
nephrotic syndrome type 7
info · Genetic
A familial nephrotic syndrome characterized by onset in the first decade of life of progressive renal disease with proteinuria and membranoproliferative glomerulonephritis that has_material_basis_in homozygous or compound heterozygous mutation in the DGKE gene
A familial nephrotic syndrome characterized by onset in the first decade of life of progressive renal disease with proteinuria and membranoproliferative glomerulonephritis that has_material_basis_in homozygous or compound heterozygous mutation in the DGKE gene on chromosome 17q22.
Signs and symptoms
- Membranoproliferative glomerulonephritis
- Proteinuria
- Nephrotic syndrome
- Hypoalbuminemia
- Podocyte foot process effacement
- Acute kidney injury
- Thickened glomerular basement membrane
- Stage 5 chronic kidney disease
- Hemolytic-uremic syndrome
- Hemolytic anemia
Also known as: Ig-mediated MPGN; Ig-mediated membranoproliferative glomerulonephritis; Immunoglobulin-mediated MPGN; immunoglobulin-mediated membranoproliferative glomerulonephritis; nephrotic syndrome type 7 with membranoptoliferative glomerulonephritis