Paget disease of bone 3

A Paget's disease of bone that has_material_basis_in heterozygous mutation in the SQSTM1 gene on chromosome 5q35.

Signs and symptoms

• Bone pain
• Patchy osteosclerosis
• Elevated circulating alkaline phosphatase concentration
• Recurrent long bone fractures
• Osteosarcoma
• Osteolysis
• Hearing impairment

Also known as: Paget's disease of bone-3