Conditions / Genetic
Parkinson's disease 15
info · Genetic
An early-onset Parkinson's disease that has_material_basis_in mutation in the FBXO7 gene on chromosome 22q12.3.
Signs and symptoms
- Talipes equinovarus
- Babinski sign
- Dysarthria
- Gait imbalance
- Lower limb spasticity
- Postural instability
- Parkinsonism with favorable response to dopaminergic medication
- Intellectual disability
- Hyperreflexia
- Scissor gait
Also known as: Parkinsonian-pyramidal syndrome; autosomal recessive early-onset Parkinson disease 15; autosomal recessive early-onset Parkinson's disease 15; pallidopyramidal syndrome