Parkinson's disease 22

info · Genetic

A late onset Parkinson's disease that has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the coiled-coil-helix-coiled-coil-helix domain containing 2 gene on chromosome 7p11.2.

Signs and symptoms

Gait disturbance
Resting tremor
Bradykinesia
Rigidity
Parkinsonism with favorable response to dopaminergic medication
Postural instability
Constipation
Hyperreflexia
Orthostatic hypotension
Depression

Also known as: autosomal dominant Parkinson's disease 22