Parkinson's disease 25

info · Genetic

An early-onset Parkinson's disease characterized by mild to moderately impaired intellectual development that has_material_basis_in homozygous or compound heterozygous mutation in the PTPA gene on chromosome 9q34.11.

Signs and symptoms

Parkinsonism with favorable response to dopaminergic medication
Intellectual disability
Bradykinesia
Resting tremor
Restless legs
Depression
Rigidity
Anxiety
Disinhibition
Drooling

Also known as: PARK25; autosomal recessive early-onset Parkinson disease 25 with impaired intellectual development