pituitary adenoma 3

A pituitary adenoma characterized by development of predominantly GH-secreting pituitary adenomas but also in some patients ACTH-secreting adenomas that has_material_basis_in somatic mutation in the GNAS gene on chromosome 20q13.32.

Signs and symptoms

• Pituitary growth hormone cell adenoma
• Increased circulating prolactin concentration
• Increased circulating ACTH level
• Acral overgrowth
• Hyperpigmentation of the skin
• Elevated circulating growth hormone concentration
• Increased circulating cortisol level
• Pituitary corticotropic cell adenoma

Also known as: PITA3; pituitary adenoma 3, multiple types