Conditions / Skin
PLACK syndrome
info · Skin
An skin disease characterized by peeling skin in association with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads that has_material_basis_in homozygous mutation in the CAST gene on chromosome 5q15.
Signs and symptoms
- Epidermal acanthosis
- Acantholysis
- Abnormal blistering of the skin
- Scaling skin
- Follicular hyperkeratosis
- Hyperkeratosis
- Leukonychia
- Angular cheilitis
- Fragile skin
- Cheilitis
Also known as: peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads