platelet-type bleeding disorder 8

A blood platelet disease characterized by mild to moderate mucocutaneous bleeding and absence of adenosine phosphate induced platelet aggregation that has_material_basis_in homozygous or compound heterozygous mutation in the P2RY12 gene on chromosome 3q.

Signs and symptoms

• Abnormal bleeding
• Ecchymosis
• Bruising susceptibility
• Persistent bleeding after trauma
• Prolonged bleeding after surgery
• Epistaxis
• Impaired ADP-induced platelet aggregation

Also known as: ADP platelet receptor P2Y12 defect; P2Y12 defect