postural orthostatic tachycardia syndrome

A heart conduction disease characterized by orthostatic intolerance that has_material_basis_in heterozygous mutation in the SLC6A2 gene on chromosome 16q12.2.

Signs and symptoms

• Elevated urinary norepinephrine level
• Orthostatic tachycardia

Also known as: familial orthostatic tachycardia due to norepinephrine transporter deficiency; irritable heart; mitral valve prolapse syndrome; orhtostatic intolerance; orthostatic intolerance due to NET deficiency