primary failure of tooth eruption

A tooth disease characterized by incomplete tooth eruption despite the presence of a clear eruption pathway that has_material_basis_in heterozygous mutation in the PTHR1 gene on chromosome 3p21.31.

Signs and symptoms

• Failure of eruption of permanent teeth
• Hypodontia
• Persistence of primary teeth

Also known as: PFE; dental noneruption; familial posterior openbite malocclusion; nonsyndromic primary failure of eruption; primary retention of teeth