primary ovarian insufficiency 15

A primary ovarian insufficiency that is characterized by onset of oligomenorrhea in the third decade of life, with small ovaries, reduced number of follicles, and elevated gonadotropic hormones and that has_material_basis_in homozygous mutation in the FANCM ge

A primary ovarian insufficiency that is characterized by onset of oligomenorrhea in the third decade of life, with small ovaries, reduced number of follicles, and elevated gonadotropic hormones and that has_material_basis_in homozygous mutation in the FANCM gene on chromosome 14q21.

Signs and symptoms

• Irregular menstruation
• Elevated circulating follicle stimulating hormone level
• Decreased circulating antimullerian hormone circulation
• Secondary amenorrhea
• Oligomenorrhea