primary ovarian insufficiency 16

A primary ovarian insufficiency that is characterized by onset of amenorrhea early in the fourth decade of life, accompanied by elevated follicle-stimulating hormone levels and low estradiol levels and that has_material_basis_in heterozygous mutation in the BN

A primary ovarian insufficiency that is characterized by onset of amenorrhea early in the fourth decade of life, accompanied by elevated follicle-stimulating hormone levels and low estradiol levels and that has_material_basis_in heterozygous mutation in the BNC1 gene on chromosome 15q25.

Signs and symptoms

• Reduced antral follicle count
• Premature ovarian insufficiency
• Elevated circulating follicle stimulating hormone level
• Decreased serum estradiol