progressive supranuclear palsy

A movement disease that is characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain.

Signs and symptoms

• Bradykinesia
• Rigidity
• Gait imbalance
• Neurofibrillary tangles
• Senile plaques
• Micrographia
• Cerebral atrophy
• Dysphagia
• Dysarthria
• Postural instability

Also known as: Steele-Richardson-Olszewski syndrome; progressive supranuclear ophthalmoplegia