Conditions / Genetic
prothrombin deficiency
info · Genetic
A thrombophilia that is characterized by bleeding symptoms due to low levels of circulating prothrombin, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding coagulation factor II, also
A thrombophilia that is characterized by bleeding symptoms due to low levels of circulating prothrombin, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding coagulation factor II, also known as prothrombin, on chromosome 11p11.
Signs and symptoms
- Menorrhagia
- Prolonged bleeding time
- Ecchymosis
- Joint hemorrhage
- Prolonged prothrombin time
- Bruising susceptibility
- Epistaxis
- Gastrointestinal hemorrhage
- Gingival bleeding
- Prolonged partial thromboplastin time
Also known as: Congenital factor II deficiency; Hereditary factor II deficiency disease; hypoprothrombinemia