prune belly syndrome

A syndrome that is characterized by megacystis with disorganized detrusor muscle, cryptorchidism, and thin abdominal musculature with overlying lax skin and that has_material_basis_in homozygous mutation in the CHRM3 gene on chromosome 1q43.

Signs and symptoms

• Congenital posterior urethral valve
• Slow pupillary light response
• Xerostomia
• Oligohydramnios
• Congenital hip dislocation
• Anal atresia
• Talipes equinovarus
• Hydroureter
• Aplasia of the abdominal wall musculature
• Pectus excavatum

Also known as: Eagle-Barrett syndrome; Obrinsky syndrome; abdominal muscle deficiency syndrome; triad syndrome