pustular psoriasis 14

A psoriasis characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein that has_material_basis_in homozygous or compound heterozygous mutat

A psoriasis characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein that has_material_basis_in homozygous or compound heterozygous mutation in the IL36RN gene on chromosome 2q14.

Signs and symptoms

• Parakeratosis
• Epidermal acanthosis
• Elevated circulating C-reactive protein concentration
• Increased total neutrophil count
• Psoriasiform dermatitis
• Increased total leukocyte count
• Pustule
• Erythema
• Fever
• Geographic tongue

Also known as: acrodermatitis continua of Hallopeau; deficiency of IL-36R antagonist