selective pituitary thyroid hormone resistance

A hyperthyroidism characterized by mild to moderate hyperthyroidism, impaired pituitary response to thyroid hormone, elevated levels of thyroid hormone, and association with thyrotoxic features that has_material_basis_in heterozygous mutation in the THRB gene

A hyperthyroidism characterized by mild to moderate hyperthyroidism, impaired pituitary response to thyroid hormone, elevated levels of thyroid hormone, and association with thyrotoxic features that has_material_basis_in heterozygous mutation in the THRB gene on chromosome 3p24.2.

Signs and symptoms

• Hyperthyroidism
• Elevated circulating thyroid-stimulating hormone concentration
• Impaired sensitivity to thyroid hormone

Also known as: PRTH; familial hyperthyroidism due to inappropriate thyrotropin secretion; pituitary resistance to thyroid hormone; selective pituitary resistance to thyroid hormone