Sneddon syndrome

An artery disease that is characterized by onset of livedo reticularis in the second decade and onset of cerebrovascular disease in early adulthood and that has_material_basis_in compound heterozygous mutation in the CECR1 gene (ADA2) on chromosome 22q11.

Signs and symptoms

• Stroke
• Livedo reticularis
• Bicuspid aortic valve
• Decreased total lymphocyte count
• Decreased circulating IgM concentration
• Impaired distal tactile sensation
• Livedo
• Livedo racemosa
• Atrophic scars
• Hypertension

Also known as: Idiopathic livedo reticularis with systemic involvement