spermatogenic failure 27

A spermatogenic failure characterized by multiple morphologic abnormalities of the sperm flagella, loss of the central pair of microtubules, loss of the inner dynein arms, and peripheral doublet disorganization of the flagella that has_material_basis_in homozy

A spermatogenic failure characterized by multiple morphologic abnormalities of the sperm flagella, loss of the central pair of microtubules, loss of the inner dynein arms, and peripheral doublet disorganization of the flagella that has_material_basis_in homozygous or compound heterozygous mutation in AK7 on chromosome 14q32.2.

Signs and symptoms

• Coiled sperm flagella
• Male infertility
• Reduced sperm motility
• Absent sperm axoneme central pair complex
• Absent sperm flagella
• Short sperm flagella

Also known as: SPGF27