spermatogenic failure 86

A spermatogenic failure characterized by acrosomal defects of the spermatozoa, resulting in oocyte activation deficiency and fertilization failure, that has_material_basis_in homozygous or compound heterozygous mutation in the ACTL7A gene on chromosome 9q31.3.

Signs and symptoms

• Male infertility
• Acephalic spermatozoa
• Ruffled acrosome
• Acrosomal hypoplasia
• Abnormal sperm head morphology

Also known as: SPGF86