spinocerebellar ataxia 6

An autosomal dominant cerebellar ataxia that is characterized by progressive ataxia, has_material_basis_in mutation in the CACNA1A gene.

Signs and symptoms

• Cerebellar atrophy
• Progressive cerebellar ataxia
• Ataxia
• Slurred speech
• Gaze-evoked horizontal nystagmus
• Dysphagia
• Dysarthria
• Abnormal vestibulo-ocular reflex
• Impaired smooth pursuit
• Sensory neuropathy