thrombophilia due to activated protein C resistance

info · Genetic

A thrombophilia characterized by resistance of F5 to cleavage and inactivation and increased tendency for thrombosis that has_material_basis_in heterozygous mutation in F5 on chromosome 1q24.2.

Signs and symptoms

Resistance to activated protein C
Hypercoagulability
Deep venous thrombosis
Prolonged partial thromboplastin time

Also known as: APC resistance; PCCF deficiency; PROC cofactor deficiency; THPH2; activated protein C resistance