thyroid hormone resistance syndrome

Signs and symptoms

• Elevated circulating thyroglobulin concentration
• Delayed speech and language development
• Increased circulating free T4 concentration
• Increased circulating free T3
• Goiter
• Impaired sensitivity to thyroid hormone
• Increased body weight
• Increased circulating T4 concentration
• Anti-thyroid peroxidase antibody positivity
• Fatigue

Also known as: Generalized thyroid hormone resistance; Refetoff syndrome; Thyroid hormone responsiveness defect; thyroid hormone resistance