tooth and nail syndrome

A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particu

A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

Signs and symptoms

• Hypoplastic fifth toenail
• Concave nail
• Agenesis of permanent teeth
• Ridged nail
• Nail pits
• Microdontia of primary teeth
• Fine hair
• Abnormal sweat gland morphology
• Sparse hair

Also known as: Hypoplastic enamel-onycholysis-hypohidrosis syndrome; Witkop's syndrome