Worth syndrome

A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate.

Signs and symptoms

• Sclerotic vertebral body
• Hyperostosis
• Clavicular sclerosis
• Growth abnormality
• Metacarpal diaphyseal endosteal sclerosis
• Sensorineural hearing impairment
• Thickened cortex of long bones
• Torus palatinus
• Metatarsal diaphyseal endosteal sclerosis
• Dental malocclusion

Also known as: Worth's syndrome; autosomal dominant endosteal hyperostosis; autosomal dominant osteosclerosis; benign form of Worth hyperostosis corticalis generalisata with torus platinus