Conditions / Immune

X-linked lymphoproliferative syndrome 2

info · Immune · ICD-10: D82.3

A lymphoproliferative syndrome characterized by X-linked inheritance, immune dysregulation after viral infect that may include lymphohystiocytosis, hypogammaglobulinemia and/or splenomegaly and that has_material_basis_in mutation in the XIAP gene on chromosome

A lymphoproliferative syndrome characterized by X-linked inheritance, immune dysregulation after viral infect that may include lymphohystiocytosis, hypogammaglobulinemia and/or splenomegaly and that has_material_basis_in mutation in the XIAP gene on chromosome Xq25.

Signs and symptoms

  • Fever
  • Splenomegaly
  • Hepatitis
  • Hypertriglyceridemia
  • Hypofibrinogenemia
  • Increased circulating ferritin concentration
  • Decreased circulating immunoglobulin concentration
  • Inflammation of the large intestine
  • Colitis
  • Recurrent skin infections

Also known as: XIAP deficiency; XLP2