X-linked parkinsonism-spasticity syndrome

info · Genetic

A movement disease characterized by slowly progressive development of parkinsonian features and variably penetrant spasticity that has_material_basis_in hemizygous mutation in the ATP6AP2 gene on chromosome Xp11.4.

Signs and symptoms

Resting tremor
Parkinsonism
Cogwheel rigidity
Spasticity
Bradykinesia
Hypomimic face
Babinski sign
Hyperreflexia

Also known as: X-linked Parkinsonism with spasticity; XPDS