X-linked spermatogenic failure 9

info · Genetic

A spermatogenic failure that is characterized by male infertility due to nonobstructive azoospermia resulting from maturation arrest that has_material_basis_in hemizygous mutation in the RBBP7 gene on chromosome Xp22.

Signs and symptoms

Elevated circulating luteinizing hormone level
Male infertility
Elevated circulating follicle stimulating hormone level
Decreased serum testosterone concentration
Leydig cell neoplasia
Decreased testicular size
Spermatogenesis maturation arrest
Non-obstructive azoospermia
Neoplasm
Lymphadenopathy